منابع مشابه
Microbial nitrosamine formation in palm wine: in vitro N-nitrosation by cell suspensions.
The ability of certain species of bacteria and yeasts that usually contaminate fresh palm sap to induce the formation of the carcinogen dimethylnitrosamine from suitable precursors (trimethylamine, dimethylamine, nitrate, and nitrite) was investigated in vitro under neutral and acid pH conditions. In the incubation media containing cell suspensions of each species of test organism, namely, Aero...
متن کاملProphage induction of Escherichia coli (lambda) by N-nitrosamines.
Carcinogenic N-nitrosamines were tested for their ability to induce lambda in a lysogenic strain of Escherichia coli K-12 (58-161 F+ Dimethylnitrosamine, di-n-propylnitrosamine, methyl-n-propylnitrosamine, and N-nitrosopiperidine were shown to be inducers of prophage.
متن کاملMorphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine.
The sequential changes in tubular epithelium following single i.p. injections of dimethylnitrosamine in carcinogenic doses were followed from 24 hr up to the development of renal adenocarcinomas. The acute changes involved, in particular, the first segment of the proximal tubules, although at higher doses the distal tubules next to glomeruli were also invariably affected. The acute alterations ...
متن کاملAlteration of hepatocytes by subcarcinogenic exposure to n-2-fluorenylacetamide.
These experiments examined the effects of a single, subcarcinogenic dose of dimethylnitrosamine or N-hydroxyfluorenylacetamide when administered after a subcarcinogenic dietary regimen of N-2-fluorenylacetamide. Control rats that received either carcinogen diet alone or a single dose of carcinogen demonstrated neither hepatic nodules nor hepatocellular carcinomas. Those animals that received di...
متن کاملAlkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes.
Freshly prepared rat hepatocytes isolated by perfusion with collagenase were able to metabolize microM concentrations of dimethylnitrosamine to a methylating agent. The methylation of hepatocyte DNA in this system was complete within 2 hr, and after this time, the content of O6-methylguanine in the DNA declined, showing that the repair system for this product was active in the isolated hepatocy...
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تاریخ انتشار 2001